Dermatologic System Practice Test Questions

Last Updated on March 25, 2025

Dermatologic System Practice Test Questions Answers for Physician Assistant Exam PANCE. This sample quiz consists of 20 multiple-choice questions on the Dermatologic System. Integumentary system: Protects the internal structures of the body from damage, prevents dehydration, stores fat, and produces vitamins and hormones.

The official questions from the Dermatologic System are 5%. The tests cover Eczematous eruptions, papulosquamous diseases, desquamation, vesicular bullae, acneiform lesions, verrucous lesions, insects/parasites, neoplasms, hair and nails, viral diseases, bacterial infections, fungal infections, and other conditions.

Dermatologic System Practice Test Questions

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Dermatologic System Practice Test Questions

1) A 60-year-old male with poorly controlled diabetes presents with a bright red erythematous rash in the groin folds. There is some satellite pustule formation near the edges of the rash. KOH prep shows budding yeast with pseudohyphae. Which of the following is the most appropriate treatment?

2) Molluscum contagiosum is a skin disorder caused by which of the following?

3) A 45-year-old female presents with rough, scaly plaques on the backs of her hands and forearms. She works as a landscaper and is frequently outdoors. A biopsy shows atypical keratinocytes confined to the epidermis. Which of the following is the most likely diagnosis?

4) A 35-year-old female presents with a “butterfly rash” across her nose and cheeks that gets worse with sun exposure. She also has arthralgias and low-grade fevers. Laboratory findings are significant for antinuclear antibodies (ANA). Which of the following is the most likely diagnosis?

5) A 27-year-old man presents with painful, erythematous nodules on the anterior surface of both lower legs. He has also had fatigue, low-grade fevers, and joint pains for the past week. Which of the following is the most likely diagnosis?

6) A 30-year-old woman complains of a painless, hyperpigmented patch on her face that has gradually enlarged over time. She reports that it worsens with sun exposure and notes that she is on oral contraceptives. Which of the following is the most likely diagnosis?

7) A 16-year-old male presents to his PCP complaining of a mildly pruritic rash that started two days ago. About a week before the rash, he had a large “patch” on his trunk, which resolved. Past medical history is noncontributory. He is not sexually active, and family history is essentially negative. Physical examination reveals salmon-colored plaques with light scale that are oriented in a “Christmas tree” pattern. KOH prep is negative. What is the most likely diagnosis?

8) A 16-year-old with a personal history of asthma and seasonal allergies presents with chronic, pruritic, eczematous lesions on the flexor surfaces of her elbows. The lesions are erythematous with lichenification from scratching. Which of the following is the most likely diagnosis?

9) Dermatophytes can be effectively identified using which of the following diagnostic procedures?

10) A 42-year-old female presents with thick, greasy, yellowish scales on her scalp, particularly around the hairline, and mild pruritus. She also notes similar patches behind her ears. Which of the following is the most likely diagnosis?

11) A 12-year-old boy complains of hair loss in a round patch on the scalp. The affected area has broken hairs at the surface and a “black dot” appearance. A KOH prep of skin scrapings is positive for hyphae. Which of the following is the best initial treatment?

12) A 28-year-old male presents with a raised, erythematous lesion on his anterior shin that has been enlarging for the past 3 weeks. It is ring-shaped with a clearer center and scaly borders. Which of the following is the most likely diagnosis?

13) Which of the following refers to a buildup of collagen in the skin?

14) A 36-year-old female complains of small, tense blisters on her trunk and proximal limbs. The blisters have a negative Nikolsky sign and are subepidermal on biopsy. Which of the following is the most likely diagnosis?

15) A 25-year-old female with a recent history of mononucleosis that resolved last week presents with a non-pruritic rash that started the day before. Examination reveals multiple target lesions of various sizes. The rash is primarily limited to the extensor surfaces of the arms and legs. What is the most likely diagnosis?

16) A 35-year-old male presents to his PCP with the complaint of scaling greasy plaques around the eyebrows and scalp. Examination reveals erythema and greasy scales around the margin of the scalp and eyebrows. Otherwise, examination is normal. What is the most effective treatment plan?

17) A 7-year-old female with a history of seasonal allergies presents to her PCP with her mother complaining of cracking, dry, and peeling hands. Her mother reports that the condition started when the patient began to play hockey last year. Topical steroids clear the condition, but it always returns. What is the most likely diagnosis?

18) A 20-year-old college student presents with itchy, purple papules on his wrists and ankles. Examination reveals lesions with fine white lines (Wickham striae) on their surface. Which of the following is the most likely diagnosis?

19) Which of the following is commonly used in conjunction with antihistamines for the treatment of mild atopic dermatitis?

20) Which of the following is a useful tool to confirm the diagnosis of dermatitis that develops on skin exposed to the sun?

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