Gastrointestinal System Practice Questions Answers

Last Updated on March 25, 2025

Gastrointestinal System Practice Questions Answers Updated for Physician Assistant Exam PANCE. This sample quiz consists of 23 multiple-choice questions on the Digestive System. The digestive system breaks down food polymers into smaller molecules to provide energy and cellular building blocks for the body.

The official questions from the Gastrointestinal System are 10%. The tests cover the Esophagus, stomach, gallbladder, pancreas, small intestine/colon, rectum, hernia, infectious and noninfectious diarrhea, vitamin and nutritional deficiencies, and metabolic disorders.

Gastrointestinal System Practice Questions Answers

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Gastrointestinal System Practice Questions

Gastrointestinal System Practice Questions Answers Updated
Physician Assistant Exam
Total Items: 23
Time Limit: NA

1) Which of the following is the proper treatment for individuals with achalasia?

2) A 65-year-old male presents to his PCP for a routine physical with complaints of fatigue, constipation, and mucus in the stool. Examination reveals heme positive stool but is otherwise negative. However, CBC reveals a HgB of 10.2 g/dl and an MCV of 68. What is the most likely diagnosis?

3) Each of the following medications may be used to treat rheumatoid arthritis EXCEPT

4) A 35-year-old female presents to the emergency room with signs and symptoms suggestive of pancreatitis. She denies a history of heavy drinking. Which of the following tests will NOT help to conclude the etiology of her condition?

5) A 25-year-old Caucasian female presents to her PCP with complaints of abdominal pain, weight loss, fatigue, and chronic diarrhea. Examination reveals a thin, cooperative female in no acute distress. She is pale and has generalized abdominal tenderness without rebound or guarding. Laboratories reveal HgB of 9.5 g/dl, MCV 68, and an elevated ESR. What is the most likely diagnosis?

6) Which of the following is the predominant bacterial pathogen responsible for chronic gastritis?

7) A 71-year-old male presents with advanced cirrhosis, caput medusa, prominent ascites, subicteric skin, and sclera. He also complains of nausea and vomiting. Which of the following procedures is relatively contraindicated for this condition?

8) Which of the following medications is commonly prescribed for maintenance treatment of Crohn’s disease?

9) Which of the following is the proper first line of treatment for individuals with diverticulitis?

10) A 55-year-old female presents to her PCP complaining of progressive fatigue, vague abdominal pain, and mild nausea. This has been going on for 5 years or more, but she has attributed it to “getting older.” Family history is essentially negative. Both her parents are living and well in their eighties. Past medical history is negative except for a blood transfusion after the birth of her first child in 1980. Laboratory examination reveals an ALT of 310 U/L and AST of 250 U/L. Alkaline phosphatase is 252 U/L. What is the most important next test?

11) A 25-year-old female patient presents at the clinic with sharp RUQ pain, nausea, and vomiting. A complete CBC, AST/ALT along with an Amylase and Lipase has been ordered. What imaging test should be done to rule out Cholelithiasis?

12) Metoclopramide is commonly prescribed in the treatment of which of the following disorders?

13) A 65-year-old male presents to his PCP for a routine physical with complaints of fatigue, constipation, and mucus in the stool. Examination reveals heme positive stool but is otherwise negative. However, CBC reveals a HgB of 10.2 g/dl and an MCV of 68. What is the most important next test?

14) A 52-year-old female presents to the emergency room with a complaint of epigastric pain that is brought on by eating. She has experienced some relief with OTC antacids. Examination reveals a diffusely tender epigastrium without rebound or guarding. Murphy’s sign is negative. What is the most specific diagnostic tool available to help diagnose this patient?

15) Photodynamic therapy (PDT) is the procedure performed in order to correct which of the following disorders?

16) A 75-year-old female patient presents with epigastric pain radiating to the back, jaundice, and weight loss. You have ordered a complete metabolic panel (CMP), amylase, trypsinogen test, and an endoscopic ultrasound (EUS). What is the suspected diagnosis?

17) A 45-year-old male presents to the ER after experiencing chest pain and dyspnea. EKG shows a prominent S wave in lead 1 and a Q wave and inverted T wave in lead 3. What is the most important NEXT test?

18) Consumption of which of the following vitamins is effective for preventing rickets?

19) A 25-year-old Caucasian female presents to her PCP with complaints of abdominal pain, weight loss, fatigue, and chronic diarrhea. Examination reveals a thin, cooperative female in no acute distress. She is pale and has generalized abdominal tenderness without rebound or guarding. What diagnostic tests would be LEAST helpful in diagnosing her condition?

20) Which of the following modalities would be used to confirm the diagnosis of a Mallory-Weiss tear?

21) Deficiency of which of the following is the main etiology for beriberi?

22) A 65-year-old male presents to his PCP complaining of epigastric pain, weight loss, and jaundice. He has a 40 packs/year history of smoking. Examination reveals hepatomegaly and generalized abdominal tenderness. Laboratory reveals alkaline phosphatase of 550 U/L and a total bilirubin of 15 mg/dL. What is the most likely diagnosis?

23) A 60-year-old male presents to his PCP with his son. The patient has been drinking heavily and skipping meals. His drinking has gradually worsened after losing his job and divorcing his wife. He is experiencing weakness, emotional lability, and myalgias. Examination reveals gait disturbance, 2/5 reflexes in all extremities, and ptosis. The patient is deficient in which of the following vitamins?

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